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David W.
Mozingo
M.D. |
RESEARCH INTERESTS:
The Burn and Wound Research Program at the University of Florida
provides a clinical patient base to permit the identification and
resolution of clinical problems that may be solved through basic and
applied research. This program integrates the activities of the
Surgical Metabolism Laboratory and the Wound Healing Research
Laboratory at the University. The research efforts concentrate on
characterizing the immune suppression that follows burn injury, and
on the mechanisms to better understand and enhance wound healing in
patients with burns and other wounds. The development of new
technology is supported by our inclusion in multicenter,
industry-sponsored research. Participation in these trials permits
access to the most current wound care technologies, and has
supported the initiation of investigator-initiated protocols as
well.
The research fellows in burns and trauma have supported this mission
resulting in publications and presentations in the area of immune
dysfunction following burns. The initiation of the T32-NIH training
grant in burns and trauma is also integral to this research program
and the current fellow is concentrating on the wound healing aspects
of our core programs.
The development of this research program has provided a reputable
foundation on which the University of Florida Burn Center and
affiliated basic science laboratories were selected for inclusion in
a Large Scale Collaborative Research Program being approved for
funding by the National Institutes of Health. This multicenter
research effort utilizes the clinical population and laboratory
capabilities of only six major burn centers in the country.
In addition to these local activities, the burn research program has
cooperated with multicenter studies organized through the
Multi-Institutional Trials Committee of the American Burn
Association. We have collaborated on two multicenter reviews of
uncommon problems admitted to burn centers, namely toxic epidermal
necrolysis syndrome and purpura fulminans.
PUBLICATIONS:
1. Schultz GS, Barillo DJ, Mozingo DW, Chin GA. Wound Bed
Preparation and a Brief History of TIME. International Wound Journal
1(1)19-32, 2004.
2. Still J, Glat P, Silverstein P, Griswold J, Mozingo D. The
Use of a Collagen Sponge/Living Cell Composite Material to Treat
Donor Sites in Burn Patients. Burns 29(8)837-841, 2003.
3. Paddock HN, Schultz GS, Baker HV, Varela JC, Beierle EA, Moldawer
LL, Mozingo DW. Analysis of Gene Expression Patterns in Human
Postburn Hypertrophic Scars. J Burn Care & Rehab. November/December
24(6)371-377, 2003.
4. Warner PM, Kagan RJ, Yakuboff KP, Kemalyan N, Palmieri TL,
Greenhalgh DG, Sheridan RL, Mozingo DW, Heimback DM, Gibran
NS, Engrav L, Saffle JR, Edelman LS, Warden DG. Current Management
of Purpura Fulminans: A Multicenter Study. J Burn Care & Rehab.
May/June 24(3)119-126, 2003.
5. McAuliffe PF, Mozingo DW. Problems in General Surgery.
Inhalation Injury and Ventilator Management. 20(1) 97-105, 2003.
6. Marko P, Layon AJ, Caruso L, Mozingo DW, Gabrielli A. Burn
Injuries. Curr Opin Anaesthesiol. 16:183-191, 2003.
7. Tasaki O, Mozingo DW, Dubick MA, Goodwin CW, Yantis LD,
Pruitt BA Jr. Effects of Heparin and Lisofylline on Pulmonary
Function After Smoke Inhalation Injury in an Ovine Model. Crit Care
Med. 30(3) 637-643, 2002.
8. Dubick MA, Carden SC, Jordan BS, Langlinais PC, Mozingo DW.
Indices of antioxidant status in rats subjected to wood smoke
inhalation and/or thermal injury. Toxicology. 176 (2002) 145-157.
9. Mozingo DW: Quality improvement guidelines for burn center
verification, http://ameriburn.org/pub/verification_QI%20Programs,
htm, American Burn Association Web Page
10. Palmiere, TL, Greenhalgh DG, Saffle JR, Spence RJ, Peck MD, Jeng
JC, Mozingo DW, Yowler CJ, Sheridan RL, Ahrenholz DH, Caruso
DM, Foster KN, Kagan RJ, Voight DW, Purdue GF, Hunt JL, Wolf S,
Molitor F, J Burn Care & Rehab March/April 23(2) 87-96, 2002.
11. Harrington DT, Mozingo DW, Cancio L, Bird P. Jordan B,
Goodwin CW. Thermally injured patients are at significant risk for
thromboembolic complications. J Trauma. March 50(3) 495-499, 2001.
12. Fukuzuka K, Edwards CK III, Clare-Salzler M, Copeland EM III,
Moldawer LL, Mozingo DW: Glucocorticoid and fas ligand
induced mucosal lymphocyte apoptosis after burn injury, J Trauma.
October 49 (4) 710-71, 2000.
13. Fukuzuka K, Edwards CK III, Clare-Salzler M. Copeland EM III,
Moldawer LL, Mozingo DW: Glucocorticoid-induced, caspase-dependent
organ apoptosis early after burn injury, Am J Physiol Regulatory
Integrative Comp Physio. 278: R1005-R1018, 2000.
14. Tasaki O, Goodwin C, Mozingo DW, Cioffi WG Jr, Ishihara
S, Brinkley WW, Dublick MA, Smith RH, Srivastava O, Pruitt BA Jr:
Selectin blockage worsened lipopolysaccharide-induced lung injury in
a swine model, J Trauma. June, 46(6): 1089-1095, 1999.
15. Ishihara S, Ward JA, Tasaki O, Brinkley WW, Seraile LG, Pruitt
BA Jr, Mozingo DW: Effects of long-term hemofiltration on
circulating mediators and superoxide production during continuous
endotoxin administration, J Trauma. May, 46(5): 894-89, 1999.
16. Ishihara S, Ward JA, Tasaki O, Pruitt BA Jr, Javors MA, Cassidy
RA, Mozingo DW: Biphasic changes in left ventricular function
during hyperdynamic endotoxemia, Am J Physiol. May, 276(5
Pt2):R1516-R1524, 1999.
17. Fukuzuka K, Rosenberg JJ, Gaines GC, Edwards CK III, Clare-Salzier
M, McKay LD, Moldawer LL, Copeland EM III, Mozingo DW:
Caspase-3-dependent organ apoptosis early after burn injury, Ann
Surg. 229(6), 1999.
18. DuBose CM, Groher MG, Mann GC, Mozingo DW. Pattern of
Dysphagia RecoveryAfter Thermal Burn Injury. Journal of Burn
Care & Rehabilitation, 26(3)233-237,2005.
19. ABA Board of Trustees: Gamelli, RL, Purdue GF, Greenhalgh DG,
Yurt RW, Kagan RJ, Kealey GP, Sheridan RT, Ratterson DR, Yurko LC,
Gillespie PW, Bennett BK, Solem LD, Jordan MH, Saffle JR, AMA
Committee on Organization and Delivery of Burn Care: Gibran NS,
Fields AM, Cain VJ, Klein MB, Mozingo DW, et al. Disaster
Management and the ABA Plan. Journal of Burn Care &
Rehabilitation 26(2)102 106, 2005.
20. Mozingo DW, Barillo, DJ, Holcomb JB. The Pope Air
Force Base Aircraft Crash and Burn Disaster. Journal of Burn
Care & Rehabilitation, 26(2)132-140, 2005.
21. Jordan MH, Mozingo DW, Gibran NS, Barillo DJ, Purdue
GF. Plenary Session II: American Burn Association Disaster
Readiness Plan. Journal of Burn Care & Rehabilitation
26(2)183-191, 2005.
22. Dimick A, Cope DN, Barillo D, Gillespie R, Mozingo D.
Report on a More Rational Approach to Managed Care for Burns.
Journal of Burn Care & Rehabilitation 26(1)14-18, 2005.
23. Feezor RJ, Paddock HN, Baker HV, Varela JC, Barreda J,
Moldawer LL, Schultz GS, Mozingo DW. Temporal Patterns of
Gene Expression in Murine Cutaneous Burn Wound Healing. Physiol
Genomics 16: 341-348, 2004.
24. Still J, Glat P, Silverstein P, Griswold J, Mozingo D.
The Use of a Collagen Sponge/Living Cell Composite Material to Treat
Donor Sites in Burn Patients. Burns 29(8)837-841, 2003.
25. Paddock HN, Schultz GS, Baker HV, Varela JC, Beierle EA,
Moldawer LL, Mozingo DW. Analysis of Gene Expression
Patterns in Human Postburn Hypertrophic Scars. J Burn Care & Rehab.
November/December 24(6)371-377, 2003.
26. Warner PM, Kagan RJ, Yakuboff KP, Kemalyan N, Palmieri TL,
Greenhalgh DG, Sheridan RL, Mozingo DW, Heimback DM, Gibran
NS, Engrav L, Saffle JR, Edelman LS, Warden DG. Current Management
of Purpura Fulminans: A Multicenter Study. J Burn Care & Rehab.
May/June 24(3)119-126, 2003.
27. Tasaki O, Mozingo DW, Dubick MA, Goodwin CW, Yantis
LD, Pruitt BA Jr. Effects of Heparin and Lisofylline on Pulmonary
Function After Smoke Inhalation Injury in an Ovine Model. Crit Care
Med. 30(3) 637-643, 2002.
28. Dubick MA, Carden SC, Jordan BS, Langlinais PC, Mozingo DW.
Indices of antioxidant status in rats subjected to wood smoke
inhalation and/or thermal injury. Toxicology. 176 (2002) 145-157.
29. Palmiere, TL, Greenhalgh DG, Saffle JR, Spence RJ, Peck MD,
Jeng JC, Mozingo DW, Yowler CJ, Sheridan RL, Ahrenholz DH,
Caruso DM, Foster KN, Kagan RJ, Voight DW, Purdue GF, Hunt JL, Wolf
S, Molitor F, J Burn Care & Rehab March/April 23(2) 87-96, 2002.
30. Harrington DT, Mozingo DW, Cancio L, Bird P. Jordan B,
Goodwin CW. Thermally injured patients are at significant risk for
thromboembolic complications. J Trauma. March 50(3) 495-499, 2001.
31. Fukuzuka K, Edwards CK III, Clare-Salzler M, Copeland EM III,
Moldawer LL, Mozingo DW: Glucocorticoid and fas ligand
induced mucosal lymphocyte apoptosis after burn injury, J Trauma.
October 49 (4) 710-71, 2000.
32. Fukuzuka K, Edwards CK III, Clare-Salzler M. Copeland EM III,
Moldawer LL, Mozingo DW: Glucocorticoid-induced, caspase-dependent
organ apoptosis early after burn injury, Am J Physiol Regulatory
Integrative Comp Physio. 278: R1005-R1018, 2000.
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