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Richard J.
Howard
M.D., Ph.D. |
RESEARCH INTERESTS:
Surgery IV has a main interest in abdominal organ transplantation, hepatobiliary surgery, endocrine surgery, and surgical infections. Research activities occur in these areas. This division carries out outcomes research in organ transplant recipients. A database is maintained that tracks all organ transplant recipients performed at the University of Florida. In addition, we have access to the national database that has all organ transplant procedures performed in the United States. We also participate in drug trials that test new immunosuppressive drugs.
In cooperation with other scientists we are participating in three-dimensional reconstruction of images of the liver and biliary tree and virtual reality. The division is also doing research in
ischemia-reperfusion injury.
Dr. Howard's main focus of research is outcomes research in organ transplant recipients and in organ donors. Clinical trials of new therapeutic measures in organ transplant recipients are also carried out with special interest in immunosuppressive agents and
anti-infectives.
PUBLICATIONS:
1. Scornik JC, Lauwers GY, Reed AI, Howard RJ, Dickson RC, Rosen CB: Infusion of donor spleen cells and rejection in liver transplant recipients. Clinical Transplantation 2000; 14:55-60.
2. Howard RJ, Thai VB, Patton PR, Hemming AW, Reed AI, Van der Werf
WJ, Fujita S, Karlix J, Scornik JC: Obese kidney transplant patients have good outcomes. Transplant Proc, 2001, 33:3420-3421.
3. Scornik JC, Clapp W, Patton PR, Van der Werf WJ, Hemming AW, Reed AI,
Howard RJ: Outcome of kidney transplants in patients known to be flow cytometry crossmatch positive. Transplantation 2001, 71: 1098-1102.
4. Hemming AW, Cattral, MS, Reed AI, Van der Werf WJ, Greig PD, Howard
RJ: Liver transplantation for hepatocellular carcinoma. Ann Surg 2001, 233:652-659.
5. Langham MR Jr, Tzakis AG, Gonzalez-Peralta R, Thompson JF, Rosen CB, Nery JR, Reed AI, Ruiz P, Van der Werf
WJ, Hemming A, Howard RJ: Graft survival in pediatric liver transplantation. J Pediatr Surg 2001, 36:1205-1209.
6. Scornik JC, Soldevilla-Pico C, Van der Werf WJ, Hemming AW, Reed AI, Langham
MR, Jr., Howard RJ: Susceptibility of liver allografts to high or low concentrations of preformed antibodies as measured buy flow
cytometry. Am J Transplant 2001; 1: 152-156.
7. Hemming AW, Langham MR, Reed AI, Van der Werf WJ, Howard RJ. Resection of the inferior vena cava for hepatic malignancy. American Surgeon 2001: 67: 1081-1087.
8. Howard RJ, Thai VB, Patton PR, Hemming AW, Reed AI, Van der Werf
WJ, Fujita S, Karlix JL, Scornik JC: Obesity does not portend a bad outcome for kidney transplant recipients. Transplantation, 2002, 73:53-55.
9. Nelson DR, Soldevilla-Pico C, Reed A, Abdelmalek MF, Hemming AW, Van der Werf
WJ, Howard R, Davis GL: The effect of anti-interleukin-2 receptor therapy on the course of hepatitis C recurrence after liver transplantation. Liver Transplantation, in press.
10. Howard RJ, Reed AI, Hemming AW, Van der Werf WJ, Patton PR, Pfaff WW, Srinivas
TR, Scornik JC. Graft loss and death: changing causes after kidney transplantation. Transplant Proc, 2001; 33: 3416.
11. Howard RJ, Reed AI, Hemming AW, Van der Werf WJ, Patton PR, Pfaff WW, Srinivas
TR, Scornik JC. Obese patients have good outcomes. Transplant Proc, 2001; 33: 3420-1.
12. Howard RJ, Reed AI, Van der Werf WJ, Hemming AW, Patton PR, Scornik
JC: What happens to renal transplant recipients who lose their grafts? Am J Kid Dis 2001, 38: 31-35.
13. Howard RJ, Patton PR, Reed AI, Hemming AW, Van der Werf
WJ, Pfaff WW, Srinivas TR, Scornik JC. The changing causes of graft loss and death after kidney transplantation. Transplantation 2002;
14. Van der Werf WJ, Howard RJ, et al. Is perfusion of cadaveric kidney grafts associated with a decreased risk for delayed graft function? Transplantation, in press.
15. Verne GN, Hocking MP, Davis RH, Howard RJ, Sabetai MM, Mathias JR, Schuffler MD, Sninsky CA. Long-term response to subtotal colectomy in colonic inertia. J Gastrointestinal Surgery 2002; 6: 728-744.
16. Hemming AW, Reed AI, Langham Mr, Fujita S, Van der Werf WJ, Howard
RJ. Hepatic vein reconstruction for resection of hepatic tumors. Ann Surg 2002; 235:850-8.
17. Hemming AW, Reed AI, Howard RJ, Fujita S, Hochwald SN, Caridi J, Hawkins IF, Vauthey
JN. Preoperative portal vein embolization for extended hepatectomy. Ann Surg 2003; 237:686-93.
18. Solis DR, Hemming AW, Reed A, Van der Werf WJ, Fujita S, Howard
RJ: Clostridial infection in a liver transplant recipient. Clinical Transplantation 2003, in press.
19. Reiner M, Cornell D, Howard RJ: Development of a successful non-heart-beating organ donation program. Progress in Transplantation 2003; 13: 225-31.
20. Kaplan B, Schold J, Srinivas T, Womer K, Foley D, Patton P, Howard
R, Meier-Kreische H-U: Effect of Sirolimus withdrawal in patients with deteriorating renal function. (Submitted)
ABSTRACTS:
1. Langham MR, Tzakis AG, Rosen CB, Nery JR, Hemming A, Ruiz P, Reed AI, Van der Werf
WJ, Gonzalez-Peralta R, Howard RJ, Thompson JF: Graft survival in children receiving liver transplants. American Academy of Pediatrics 2000 Annual Meeting, October 28, 2000.
BOOKS AND BOOK CHAPTERS:
1. Janelle J, Howard RJ. Viral infections. American College of Surgeons Mannual of Preoperative and Postoperative Care. Scientific American Press, 2000.
2. Howard RJ: Organ donation: social policy, ethical, and legislative implications. Rodrigue J, ed: The Biopsychosocial Perspectives in Transplantation. Kluwer Academic/Plenum Pub., New York, 2001 pp.39-58.
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