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Stephen R. Grobmyer
M.D.
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RESEARCH INTERESTS:
▪ Cancer Nanotechnology
▪ Breast Cancer imaging and treatment
▪
Soft Tissue
Sarcoma
▪
Pancreatic Cancer
CURRENT
RESEARCH:
NCI R01(CA90533)
Role: Co-PI, PI: Huabei Jiang, PhD
Optical
imaging of breast cancer
Dates: 5/06/02-4/30/07
Ortho Biotech Clinical Affairs, LLC
Role: PI
Placebo-controlled pilot study to assess the post-operative
administration of Epoetin alpha on patients undergoing abdominal or
pelvic surgery for malignancy
Dates: 11/01/05-11/01/06
James and Esther King Biomedical Research
Role: PI
Metabolically targeted nanoshells for high resolution in vivo
imaging of cancer with finite element based Photoacoustic tomography
Dates: 7/1/06-6/30/09
Department of Surgery- Research Career Development Award
Role: PI
Novel ICG Nanoparticles for in-vivo photothermal ablation
PUBLICATIONS:
1. Grobmyer, S.R., Reith, J.D., Schahlaee, A., Bush, C.H.,
Hochwald, S.N. "Malignant Peripheral Nerve Sheath Tumor: Molecular
Pathogenesis and Current Management Considerations." Seminars in
Surgical Oncology (in press,), 2007.
2. Indelicato, D.J., Grobmyer S.R., Newlin, H., Morris, C.G.,
Haigh, L.S., Copeland, E.M. 3rd, Mendenhall, N.P. "The Association
Between Surgical Closure Type and Acute Infection, Local Recurrence,
and disease surveillance in Patients Undergoing Breast Conserving
Therapy for Early Stage Breast Cancer" Surgery (in press),
2007.
3. Eilber, F.C., Brennan, M.F., Eilber, F.R., Eckardt, J.J.,
Grobmyer, S.R., Riedel, E., Forscher, C., Maki, R.G., Singer,
S. "Chemotherapy is Associated with Improved Survival in Adult
Patients with Primary Extremity Synovial Sarcoma" Annals of
Surgery (in press) 2007.
4. Wilson, J., Massol, N., Marshall, J., Copeland, E.M.,
Grobmyer, S.R. "Granulomatous Mastitis: In Search of a
Therapeutic Paradigm" American Surgeon (in press), 2007.
5. Iwakuma, N., Sharma, P., Delano, M.J., Moldawer, L., Moudgil, B.,
Grobmyer, S.R. "Differential Uptake of PEG-FITC Silica
Nanoparticles by Human Breast Cancer Cells and Normal Human Breast
Epithelial Cells." NSTI Proceedings 2:348-349, 2007.
6. Chang, D.T., Feigenberg, S.J., Indelicato, D., Morris, C.,
Lightsey, J., Grobmyer, S.R., Copeland, E.M., Mendenhall, N.P.
"Long Term Outcomes in Breast Cancer Patients with Ten or More
Positive Axillary Nodes Treated with Combined Modality Therapy: the
Importance of Radiation Field Selection." International
Journal
of Radiation Biology, and Physics, 67(4):1043-51, 2007.
7. Grobmyer, S.R., Pieracci, F., Allen, P.J., Brennan, M.F.,
Jaques, D.P. "Defining Morbidity after Pancreaticoduodenectomy: Use
of a Prospective Complication System." Journal of the American
College of Surgeons, 204(3): 356-64,2007.
8. Cardona, D., Grobmyer, S.R., Crawford, J.M., Liu, C.
"Hepatocellular Carcinoma Arising from Ectopic Liver Tissue in the
Pancreas." Virchows Archive, 450(2): 225-229, 2007.
9. Indelicato, D., Grobmyer, S.R., Copeland, E.M.,
Mendenhall, N.P. "Delayed Breast Cellulitis: An Evolving
Complication of Breast Conservation." International Journal of
Radiation Oncology, Biology, and Physics 66(5): 1339-46, 2006.
10. Cuenca, A.G., Jiang, H., Hochwald, S.N., Delano, M., Cance, W.G.,
Grobmyer, S.R. "Emerging Implications of Nanotechnology on
Cancer Diagnostics and Therapeutics." Cancer, 107(3): 459-66,
2006.
11. Winfield, R.D., Hochwald, S.N., Vogel, S.B., Hemming, A.W., Liu,
C., Cance, W.G., Grobmyer, S.R. "Presentation and
Management of Gastrointestinal Stromal Tumors of the Duodenum."
American Surgeon, 72(8): 719-22, 2006.
12. Grobmyer, S.R., Wang, L., Gonen, M., Fong, Y., Klimstra,
D., D'Angelica, M., DeMatteo, R.P., Schwartz, L., Blumgart, L.,
Jarnagin, W.R. "Perihepatic Lymph Node Assessment in Patients
Undergoing Partial Hepatectomy for Malignancy." Annals of Surgery,
244(2): 260-264,2006.
13. Tchabo, N.E., Grobmyer, S.R.,
Jarnagin, W.R., Chi, D.S. "Conservative Management of Pneumatosis
Intestinalis." Gynecologic Oncology, 99(3): 782-784, 2005.
14.
Mendenhall, W.M.,
Zlotecki, R.A., Hochwald, S.N., Hemming, A.W., Grobmyer, S.R.,
Cance, W.G. "Retroperitoneal Soft Tissue Sarcoma." Cancer 104(4):
669-75, 2005.
15.
Grobmyer,
S.R., Luther, N., Antonescu, C.R., Singer, S., Brennan, M.F. "Multiple Primary Soft Tissue Sarcomas.
Cancer 101(11): 2633-5,
2004.
16.
Grobmyer, S. R., Brennan, M.F. "The Treatment of Retroperitoneal
Sarcoma." Advances in Surgery 38: 13-29, 2004.
17. Grobmyer, S.R., Fong, Y., D'Angelica, M., DeMatteo, R.,
Blumgart, L., Jarnagin, W. "Diagnostic Laparoscopy Prior to Planned
Hepatic Resection for Colorectal Metastases." Archives of Surgery
139(12): 1326-30, 2004.
18. Grobmyer, S.R., Maki, R., Dimetri, G., Reidel, E.,
Brennan, M.F., Singer, S. "Neo-Adjuvant Chemotherapy for Primary
High Grade Extremity Soft Tissue Sarcoma." Annals of Oncology
15(11): 1667-72, 2004.
19. Hughes, D., Grobmyer, S.R., Brennan, M.F. "Preventing
Pancreaticoduodenectomy for Lymphoplasmacytic Sclerosing
Pancreatitis (LP): Cost Effectiveness of IgG4." Pancreas 29 (2):
167, 2004.
20. Grobmyer, S.R., Gollub, M.J., Shia, J., Guillem, J.G.
"Ileal Diverticulitis: Clinical and Radiographic Presentation."
Digestive Diseases and Sciences 49 (3): 498-502, 2004.
21. Grobmyer, S.R., Lieberman, M.D., Daly, J.M. "Gallbladder
Cancer: A Single Institution's Experience in the 20th Century."
World Journal of Surgery 28(1): 47-49, 2004.
22. Rivadeneira D.E., Pochapin M., Grobmyer S.R., Jacobson
I., Mackrell P., Lieberman M., Daly J.M. "Comparison of Linear Array
Ultrasound and Helical Computed Tomography for the Staging of
Periampullary Malignancies." Annals of Surgical Oncology 10
(8):890-897, 2003.
23. Hollenbeck, S., Grobmyer, S.R., Kent, K.C., Brennan M.F.
"Surgical Treatment and Outcome of Patients with Primary Inferior
Vena Cava Leiomyosarcoma." Journal of the American College of
Surgeons 197: 575-579, 2003.
24. Grobmyer, S.R., Brennan, M.F. "Predictive Factors
Detailing the Recurrence Rate of Soft Tissue Sarcoma." Current
Opinion in Oncology, 15: 319-324, 2003.
25. Grobmyer, S.R., Graham, D., Brennan, M.F., Coit, D. "High
Pressure Gradients Generated by Closed-Suction Surgical Drainage
Systems" Surgical Infections, 3 (3): 59-62, 2002.
26. Weyant, M. J., Grobmyer, S. R., Dayal, R., Barie, P. S.
"Uretheral Transection and Extraperitoneal Contrast Extravasation
with Multiple Pelvic Fractures." Journal of Trauma, 53(3): 616,
2002.
27. Grobmyer, S. R., Clary, B., Lewis, J. J., Woodruff, J.,
Brennan, M. F. "Adult Perineal Sarcomas." Journal of Surgical
Oncology, 77: 101-104, 2001.
28. Rivadeniera, D. E., Grobmyer, S. R., Naama, H.,
Subbaramaiah, K., Mackrell, P. J., Daly, J. M. "Malnutrition-Induced
Macrophage Apoptosis." Surgery, 129, 617-625, 2001.
29. Grobmyer, S. R., Naama, H., Behfarin, P, Engstad, K. and
Ko, W. "Boerhaave's Syndrome." Journal of the American College of
Surgeons, 192: 232, 2001.
30. Grobmyer, S. R., Daly, J. M., Glotzbach, R. E., Grobmyer,
A. J. "The Role of Surgery in Post-Mastectomy Extremity Angiosarcoma
(Stewart-Treves Syndrome)." Journal of Surgical Oncology, 73:
182-188, 2000.
31. Grobmyer, S. R., Rivadeneira, D. E., Mackrell, P.,
Goodman, C. A., Lieberman, M. D., Daly, J. M. "Pancreatic
Anastomotic Failure Following Pancreaticoduodenectomy" American
Journal of Surgery, 180: 117-120, 2000.
32. Grobmyer, S. R., Guillem, J. G., O'Riordian, D., Woodruff
J., Shriver, C., Brennan, M. F. "Colonic Manfestations of MEN 2B: A
Report of 4 Cases." Diseases of the Colon and Rectum, 42: 1216-1219,
1999.
33. Grobmyer, S. R., Barie, P. S., Nathan, C. F., Fuortes,
M., Lin, E., Lowry, S. F., Wright, C., Weyant, M., Reaves, F., Hydo,
L., Shiloh, M. S., Ding, A. "Secretory Leukocyte Protease Inhibitor,
an Inhibitor of Neutrophil Activation, is Elevated in Serum in Human
Sepsis and Experimental Endotoxemia." Critical Care Medicine, 28:
1276-1282, 2000.
34. Grobmyer, S. R., Lin, E., Lowry, S.F., Rivadeneira, D.
E., Potter, S., Barie, P. S., Nathan, C. F. "Elevation of IL-18 in
Human Sepsis." Journal of Clinical Immunology, 20: 212-215, 2000.
35. Weyant, M. J., Eachempati, S. R., Maluccio, M. A., Rivadeneira,
D. E., Grobmyer, S. R., Hydo, L. J., Barie, P. S.
"Interpretation of Computed Tomography Does not Correlate with
Laboratory or Pathologic Findings in Surgically Confirmed Acute
Appendicitis." Surgery, 128: 145-152, 2000.
36. Grobmyer, S. R., Armstrong, B., Nicholson, S., Gabay, C.,
Arend, W. Potter, S., Melchior, M., Fritz, L. C., Nathan, C. F.
"Peptidomimetic Fluoromethylketone Rescues Mice from Lethal
Endotoxic Shock" Molecular Medicine, 5: 585-594, 1999.
Book Chapters:
1. Grobmyer, S.R., Iwakuma, N. "Cancer Nanotechnology" in
Encyclopedia of Cancer (in press).
2. Grobmyer, S.R., Guillem, J.G. "The Management of Colon
Cancer," in Current Surgical therapy- 8th edition, ed.
J.L. Cameron, 2004.
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