Robert Winfield is currently a PGY-5 General Surgery Resident.  He recently completed two years as a trainee in the T32 Research Fellowship in Trauma and Burns in the Laboratory of Inflammation Biology and Surgical Science and is working primarily under the guidance of Dr. Lyle L. Moldawer.  He maintains active research into dysfunctional inflammatory responses of obese patients to injury and post-injury resuscitation.  Other interests include trauma and burn prevention.  He plans to pursue a career in academic pediatric or acute care surgery (trauma surgery, emergency surgery, and surgical critical care) upon completion of general surgery training.

Honors and Distinctions

2008    Florida Committee on Trauma Resident/Fellow Paper Competition – Best Clinical Paper

2008    University of Florida Department of Surgery Research Day – Best Clinical Abstract Award

2008    Eastern Association for the Surgery of Trauma - Templeton Injury Prevention Award Finalist

2003    Alpha Omega Alpha Honor Medical Society

2003    American Association for the Surgery of Trauma Medical Student Scholarship

Publications/Chapters

Winfield RD, Parr AG, Ang DN, Martin TD, Chen MK, Seagle MB, Hochwald SN, Reed AI, Lottenberg L.  “A Case of Dual Thoracoabdominal Impalement in Vehicular Trauma”.  The American Surgeon.  2008 Aug; 74(8): 757-60. 

Wynn JL, Scumpia PO, Winfield RD, Delano MJ, Barker T, Ungaro RF, Levy O, Moldawer LL.  “Defective innate immunity predisposes murine neonates to poor sepsis outcome, but is reversed by TLR agonists.”  Blood.  Sep 1;112(5):1750-8. Epub 2008 Jun 30. 

Winfield RD, Chen MK, Langham MR, Kays DW, Beierle EA.  “Ashes, Embers, and Coals: Significant Sources of Burn-Related Morbidity in Children”.  Journal of Burn Care and Research.  2008 January/February;29(1):109-113. 

Winfield RD, Ang DN, Chen MK, Kays DW, Langham MR Jr, Beierle EA. The use of Seprafilm in pediatric surgical patients.  The American Surgeon. 2007 Aug;73(8):792-5.   

Scumpia PO, Delano MJ, Kelly-Scumpia KM, Weinstein JS, Wynn JL, Xia C, Winfield RD, Chung CS, Ayala A, Heyworth PG, Reeves WH, Clare-Salzer MJ, Moldawer LL.  “Treatment with GITR agonistic antibody corrects adaptive immune dysfunction and improves survival in murine sepsis”.  Blood. 2007 Nov 15;110(10):3673-81. 

Winfield RD, Hochwald SN, Vogel SB, Hemming AW, Liu C, Cance WG, Grobmyer SR.   “Presentation and Management of Duodenal Gastrointestinal Stromal Tumors”.  The American Surgeon. 2006 Aug;72(8):719-22; discussion 722-3. 

Winfield RD, Beierle EA.  “Pediatric Surgical Issues in Meconium Disease and Cystic Fibrosis”.   Surgical Clinics of North America.  2006 Apr; 86(2): 317-21 

Winfield RD, Moldawer LL.  “Gene Therapy in Critical Illness: Past Applications and Future Potential”.  Civetta, Taylor, and Kirby – Critical Care, 4^th Edition.  In Press. 

Winfield RD, Lottenberg L.  “The Secondary and Tertiary Survey in Acute Trauma”.  Civetta, Taylor, and Kirby – Critical Care, 4^th Edition.  In Press. 

Winfield RD, Delano MJ, Scumpia PO, Moldawer LL.  “Myeloid Derived Suppressor Cells in Cancer Cachexia: A New Explanation for an Old Problem”.  Journal of Parenteral and Enteral Nutrition.  In Press. 

Winfield RD; Delano MJ; Dixon DJ; Schierding WS; Cendan JC; Lottenberg L; Hayden D; Lopez MC; Baker HV; Cobb JP; Moldawer LL; Maier RV; Cuschieri J.  “Differences in Outcome between Obese and Non-Obese Patients Following Severe Blunt Trauma are Not Consistent with an Early Inflammatory Genomic Response”.  Submitted for publication in the Journal of Critical Care Medicine. 

Presentations

Winfield RD, Delano MJ, Lottenberg L, Cendan JC, Moldawer LL, Maier RV, Cuschieri J.  “Traditional Resuscitative Practices Fail to Resolve Metabolic Acidosis in Morbidly Obese Patients Following Severe Blunt Trauma”.  Oral presentation October 24, 2008 at the Resident/Fellow Paper Competition at the Annual Meeting of the Florida Committee on Trauma, Orlando, FL.  Winner, Best Clinical Paper. 

Winfield RD, Delano MJ, Cuschieri J, Dixon D, Schierding W, Cendan JC, Baker HV, Maier RV, Cobb JP, Moldawer LL.  “Initial Genomic Response Does Not Predict Differences in Outcome Between Obese and Normal Weight Patients Following Severe Blunt Trauma”.  Poster presentation September 23, 2008 at the Annual Meeting of the American Association for the Surgery of Trauma, Maui, HI. 

Delano MJ,  Scumpia PO, Kelly-Scumpia KM, Winfield RD, Wynn JL, Moldawer LL.  “Splenic Myeloid Derived Suppressor Cell Expansion Dependence on CXCL12 Signaling During Sepsis.”  Poster presentation June 28, 2008 at the International Shock Society Annual Meeting, Cologne, Germany. 

Winfield RD, Delano MJ, Dixon D, Schierding W, Leek JT, Cendan JC, Hayden D, Lopez MC, Baker HV, Cobb JP, Moldawer LL, Maier RV, Cuschieri J.  “Initial Genomic Response does not Predict Outcome Between Obese and Normal Weight Patients Following Severe Blunt Trauma.”  Poster presentation May 13, 2008 at the 7^th Annual Colloquium of the International Sepsis Forum, Chapel Hill, NC. 

Winfield RD, Delano MJ, Lottenberg L, Cendan JC, Moldawer LL, Maier RV, Cuschieri J.  “Early Resuscitative Practices Fail to Correct Metabolic Acidosis in Morbidly Obese Trauma Patients.”  Oral presentation April 18, 2008 at the University of Florida Department of Surgery Research Day, Gainesville, FL.  Winner, Best Clinical Abstract award. 

Winfield RD, Delano MJ, Moldawer LL.  “The Role of Myeloid Derived Suppressor Cells in Cancer Cachexia.”  Poster presentation April 18, 2008 at the University of Florida Department of Surgery Research Day, Gainesville, FL. 

Islam SK, Winfield RD, Vick L, McVay M.  “Traumatic Pancreatic Injuries in Children.”  Poster presentation at the 2008 Meeting of the British Association of Paediatric Surgeons, Edinborough, Scotland, United Kingdom. 

Winfield RD, Parr AG, Ang DN, Burch PT, Chen MK, Reed AI, Hochwald SN, Martin TD, Lottenberg L.  “An Intensive Board Review Course: A Spectacular Case of Dual Impalement in Vehicular Trauma”.  Poster presentation February 11, 2008 at the 2008 Annual Meeting of the Southeastern Surgical Congress, Birmingham, AL. 

Wilson JP, Burgess G, Winfield RD, Lottenberg L.  “Sturgeons versus Surgeons: Leaping Fish Injuries at a Level I Trauma Center”.  Poster presentation February 11, 2008 at the 2008 Annual Meeting of the Southeastern Surgical Congress, Birmingham, AL. 

Winfield RD, Mozingo DW, Armstrong JH, Hollenbeck JI, Richards WT, Martin L, Lottenberg L.  “Preventing All-Terrain Vehicle Trauma: Is Legislation Really the Answer?”.  Oral presentation January 17, 2008 at the Annual Meeting of the Eastern Association for the Surgery of Trauma, Jacksonville, FL.  2008 John Templeton Injury Prevention Award finalist. 

Winfield RD, Moldawer LL, Scumpia PO, Wynn JL, Delano MJ, O'Malley KA, Moreno CO, Cance WG, Beierle EA.  “Focal Adhesion Kinase in Necrotizing Enterocolitis”.  Poster presentation October 27, 2007 in the Surgical Section at the 2007 Annual Meeting of the American Academy of Pediatrics, San Francisco, CA. 

Winfield RD, Macaulay C, Moldawer LL.  “TPV-2L Demonstrates Potent in Vitro Anti-TNF-a Activity”.  Poster presentation October 11, 2007 at the 2007 Annual Meeting of the Society for Leukocyte Biology, Cambridge, MA. 

Winfield RD, Chen MK, Langham MR, Kays DW, Beierle EA.  “Ashes, Embers, and Coals: Significant Sources of Burn-Related Morbidity in Children”.  Poster presentation April 20, 2007 at the 2007 University of Florida Department of Surgery Research Day, Gainesville, FL. 

Winfield RD, Chen MK, Langham MR, Kays DW, Beierle EA.  “Ashes, Embers, and Coals: Significant Sources of Burn-Related Morbidity in Children”.  Poster presentation March 21, 2007 at the Annual Meeting of the American Burn Association, San Diego, CA.

Winfield RD, Wynn JL, O’Malley KA, Ungaro RF, Trujillo A, Cance WG, Beierle EA, Moldawer LL.  “Focal Adhesion Kinase Expression and Activation in Intestinal Inflammation”.  Oral poster presentation March 13, 2007 at the 7^th World Congress on Trauma, Shock, Inflammation, and Sepsis, Munich, Germany. 

Wynn JL, Scumpia PO, Winfield RD, Delano MJ, O’Malley KA, Ungaro R, Abouhamze A, Moldawer LL.  “Improved Survival in Neonatal Mice with Sepsis Following TLR Agonist Treatment”.  Poster presentation March 15, 2007 at the 7^th World Congress on Trauma, Shock, Inflammation, and Sepsis, Munich, Germany. 

Delano MJ, Scumpia PO, O’Malley KA, Wynn J, Winfield RD, Moldawer LL.  “Sepsis Reprograms Bone Marrow Hematopoiesis Toward The Myeloid Lineage In A MyD88 And TRIF Dependent Manner”.  Oral presentation March 13, 2007 at the 7^th World Congress on Trauma, Shock, Inflammation, and Sepsis, Munich, Germany. 

Winfield RD, Ang DN, Langham MR, Chen MK, Kays DW, Beierle EA.  “The Use of Hyaluronate Carboxymethylcellulose (Seprafilm) in a Pediatric Population: A Retrospective Review”.  Poster presentation February 11, 2007 at the Annual Meeting of the Southeastern Surgical Congress, Savannah, GA. 

Winfield RD, Hochwald SN, Vogel SB, Hemming AW, Liu C, Cance WG, Grobmyer SR.  “Importance of Tumor Site in the Presentation and Management of Gastrointestinal Stromal Tumors”.  Oral Presentation May 26, 2006 at the Annual Meeting of the Florida Chapter of the American College of Surgeons, Boca Grande, FL. 

Winfield RD, Hochwald SN, Vogel SB, Hemming AW, Liu C, Cance WG, Grobmyer SR.  “Presentation and Management of Gastrointestinal Stromal Tumors of the Duodenum”.  Poster Presentation March 31, 2006 at the 2006 University of Florida Department of Surgery Research Day, Gainesville, FL. 

Winfield RD, Hochwald SN, Vogel SB, Hemming AW, Liu C, Cance WG, Grobmyer SR.  “Presentation and Management of Gastrointestinal Stromal Tumors of the Duodenum”.  Oral Presentation February 19, 2006 at the Annual Meeting of the Southeastern Surgical Congress, Lake Buena Vista, FL.

Submitted/Pending Abstracts and Publications

Winfield RD, Delano MJ, Lottenberg L, Cendan JC, Moldawer LL, Maier RV, Cuschieri J.  “Traditional Resuscitative Practices Fail to Resolve Metabolic Acidosis in Morbidly Obese Patients Following Severe Blunt Trauma”.  Accepted for oral presentation at the 2009 Annual Meeting of the Eastern Association for the Surgery of Trauma. 

Winfield RD, Mozingo DW, Armstrong JH, Hollenbeck JI, Richards WT, Martin L, Beierle EA, Lottenberg L.  “Florida ATV Laws Fail to Prevent ATV-Related Morbidity and Mortality”.  Accepted for poster presentation at the 2009 Annual Meeting of the Southeastern Surgical Congress.  

Winfield RD; Delano MJ; Dixon DJ; Schierding WS; Cendan JC; Lottenberg L; Lopez MC; Baker HV; Cobb JP; Moldawer LL; Maier RV; Cuschieri J.  “Differences in Outcome between Obese and Non-Obese Patients Following Severe Blunt Trauma are Not Consistent with an Early Inflammatory Genomic Response”.  Submitted for publication in the Journal of Critical Care Medicine. 

Delano MJ, Scumpia PO, Weinstein JS, Kelly-Scumpia KM, O’Malley KA, Wynn JL, Winfield RD, Moreno CO, Ramphal R, Gabrilovich DI, Reeves WH, Clare-Salzler M, Moldawer LL.  “IL-4, IL-10, and CCR2 Signaling Do Not Contribute to the Increased Myeloid Derived Suppressor Cell Numbers or Function During Polymicrobial Sepsis”.  Submitted for publication in The Journal of Leukocyte Biology. 

Delano MJ, Scumpia PO, Wynn JL, Moreno CO, O’Malley KA, Winfield RD, Moldawer LL.  “Myeloid-Derived Suppressor Cells and their Contribution to Post-Injury and Sepsis Immune Suppression”.  Submitted for publication in Blood. 

Wilson JP, Burgess G, Winfield RD, Lottenberg L.  “Sturgeons versus Surgeons: Leaping Fish Injuries at a Level I Trauma Center”.  Submitted for publication in The American Surgeon. 

Islam SK, Winfield RD, Vick L, McVay M.  “Traumatic Pancreatic Injuries in Children.”  Manuscript in preparation for publication in the Journal of Pediatric Surgery.

Invited Presentations/Discussions 

Invited Speaker           2008 University of Florida Graduate Seminars in Physiological Sciences: “Clinical, Genomic, and Physiologic Responses of the Obese Patient to Severe Traumatic Injury” 

Invited Speaker           2007 Shands at the University of Florida Trauma Multidisciplinary Conference: “ATV-related Injuries: Is Legislation Really the Answer?” 

Invited Speaker           2007 University of Florida Department of Surgery Grand Rounds: “Obesity and Critical Illness: Clinical and Genomic Features” 

Invited Speaker           2007 Shands at the University of Florida Trauma Tracks Trauma Nurse Education Series: “Traumatic Shock” 

Invited Speaker           2007 Shands at the University of Florida Trauma Resuscitation Nurse Course: “Advanced Procedures” 

Invited Speaker           2007 Shands at the University of Florida Trauma Awareness Day: “Burns to Little Feet are a BIG Problem!” 

Invited Speaker           2007 American Association of Critical Care Nurses, North Central Florida Chapter, Annual Meeting: “Pediatric Trauma: Beyond the Band-Aid”