Emina H Huang, MD

Associate Professor
General Surgery/GI, Oncologic and Endocrine Surgery

phone: (352) 265-0761
fax: (352) 265-1060

Awards and Professional Interests - Research Projects
References - Biosketch
Awards and Professional Interests
  • 1981-1984 Oberlin Shansi Memorial Association Scholarship
  • 1982-1983 NIMH Student Scholarship
  • 1984 Sigma Xi
  • 1984 Phi Beta Kappa
  • 1984 Graduation with High Honors, Oberlin College
  • 1989 Graduation with Research Honors Award for Distinguished Research in Pahtology/ Immunology, Stanford University School of Medicine
  • 1993-1994 Sandoz Medical Research Fellow in Transplant Surgery
  • 1995 Columbus Surgical Society, Second Place Award
  • 2000 Columbia University School of Medicine, Department of Surgery, Teacher of the Year
  • 2001 Royal College of Surgeons Traveling Fellowship

Research Projects
  • National Cancer Institute, K08 CA91915-01A1 “RAGE and Tumor Modulation” 80% effort, Principal Investigator, 5/02 - 4/07, $646,110, Completed
  • The Michigan Bowel Control Program. Co-investigator, 11/04 – 10/09, $600,000
  • Comprehensive Cancer Center Award (Will and Jeanne Caldwell Fund for Cancer Research), “Colon cancer stem cells”, 11/06-10/07, $25,000
  • Comprehensive Cancer Center Award (Weatherwax Foundation), “Study of ALDH1 as a marker of colon cancer stem cells”, 5/07 – 4/08, $50,000

References
  1. Andorn A, Huang E, Warren E. Specific [3H]-spiroperidol binding sites in human prefrontal cortex: potential site multiplicity and overall serotonin-like selectivity. Life Sciences 1984, 34(25): 2461-2466
  2. Huang E, Pickett J, Siegal J, Andorn A. Cations decrease specific [3H]-spiroperidol binding in human prefrontal cortex. Life Sciences 1986, 38(15): 1369-1373
  3. Lifson J, Coutre S, Huang E, and Engleman E. Role of envelope glycoprotein carbohydrate in human immunodeficiency virus (HIV) infectivity and virus-induced cell fusion. J. Exp. Med. 1986, 164: 2101-2106
  4. Morgan C, Pelletier R, Hernandez C, Teske D, Huang E, Ohye R, Ferguson R, Orosz C. Cytokine mRNA expression during development of acute rejection in murine cardiac allografts. Transplant Proc 1993, 25(1):114-116
  5. Morgan C, Pelletier R, Hernandez C, Teske D, Huang E, Ohye R, Ferguson R, Orosz C. Alloantigen-dependent endothelial phenotype and lymphokine expression in rejecting murine cardiac allografts. Transplant 1993, 55(1):919-923
  6. Huang E, Morgan C, Adams P, Ferguson R, Orosz C. Gonadal vein endothelia used to demonstrate relative endothelial versus macrophage alloantigenicity. Surgical Forum XLIII 1992, 426-429
  7. Orosz CG, Ohye RG, Pelletier RP, VanBuskirk AM, Huang E, Morgan C, Kincade PW, Ferguson RM. Treatment with anti-vascular cell adhesion molecule 1 monoclonal antibody induces long-term murine cardiac allograft acceptance. Transplant 1993, 56(2):453-460
  8. Huang EH, Morgan CJ, Sedmak DD, Ferguson RM, Orosz CG. Alloantigenicity of human endothelial cells IV. Derivation, characterization and utilization of gonadal vein endothelia (GVEC) to control endothelial alloantigenicity during lymphocyte-endothelial interactions. Transplant 1994, 57(5):703-711
  9. Huang EH, Gabler DM, Kricec ME, Gerber N, Ferguson RM, Orosz CG. Differential effects of gallium nitrate on T lymphocyte and endothelial cell activation. Transplant 1994, 58 (11):1216-1222
  10. Sedmak DD, Guglielmo AM, Knight DA, Birmingham DJ, Huang EH, Waldman WJ. Cytomegalovirus inhibits class II expression on infected endothelial cells. Am. J. Path 1994, 144(4):683-692
  11. Waldman WJ, Adams PW, Sedmak DD, Knight DA, Huang EH, Orosz CG. Radio-resistance of consecutive and cytokine-induced expression of HLA class I and II, and intercellular adhesion molecule-1 (ICAM-1) on cultured human endothelial cells. Endothelium 1994, 1:305-315
  12. Waldman WJ, Alampi NC, Knight DA, Huang EH, Orosz CG, Sedmak DD. A costimulatory factor in T cell activation by autologous CMV-infected endothelial cells. J. Cell. Biochem. 1994;Abs E140:18A
  13. Waldman WJ, Knight DA, Huang EH, Sedmak DD. Bidirectional transmission of infectious cytomegalovirus between monocytes and vascular endothelial cells: an in vitro model. J. Infectious Diseases 1995, 171(2):263-72
  14. Bergese SD, Huang EH, Pelletier RP, Widmer MB, Ferguson RM, Orosz CG. Regulation of endothelial VCAM-1 expression in murine cardiac grafts. Expression of allograft endothelial VCAM-1 can be manipulated with antagonist of IFNα or IL4 and is not required for allograft rejection. Am. J. Path 1995; 147(1):166-175
  15. Orosz CG, Bergese SD, Huang EH, VanBuskirk AM. Immunologic characterization of murine cardiac allograft recipients with long-term graft survival due to anti-VCAM-1 or anti-CD4 mAb therapy. Transplant Proc 1995; 27(1):387-388
  16. Waldman WJ, Alampi NC, Knight DA, Huang EH, Orosz CG, Sedmak DD. ICAM-1: A costimulatory factor in T cell activation by autologous or allogeneic CMV-injected endothelial cells. J. Cell. Biochem. 1995; 18A:275
  17. Orosz CG, Huang EH, Bergese SD, Sedmak DD, Birmingham DJ, Ohye RG, VanBuskirk. Prevention of acute murine cardiac allograft rejection: Anti-CD4 or anti-VCAM-1 mAbs block acute rejection but permit persistent graft-reactive alloimmunity and chronic tissue remodeling. J. Heart & Lung Transplantation 1997; 16(9): 889-904
  18. Waldman WJ, Knight DA, Huang EH. An in vitro model of T cell activation by autologous CMV-infected human adult endothelial cells: contribution of CMV-enhanced endothelial ICAM-1. J. Immunology 1998; 160: 3143 - 3151
  19. Lee S, Southall J, Gleason N, Huang E, Bessler M, Whelan R. Time course of differences in lymphocyte proliferation rates after laparotomy vs CO2 insufflation. Surg Endosc. 2000: 14(2): 145-148
  20. Lee W, Gleason N, Southall J, Allendorf J, Blanco I, Huang E, Bessler M, Whelan R. A serum-soluble factor(s) stimulates tumor growth following laparotomy in a murine model. Surg Endosc 2000 14(5): 490-494
  21. Lee SW, Southall JC, Gleason NR, Huang EH, Bessler M, Whelan RL. Lymphocyte proliferation in mice after a full laparotomy is the same whether performed in a sealed carbon dioxide chamber or in room air. Surgical Endoscopy 2000; 14(3): 225 - 238
  22. Lee W, Gleason N, Stapleton G, Zhai C, Huang E. Bessler M, Whelan R. Increased platelet-derived growth factor (PDGF) release after laparotomy stimulates systemic tumor growth in mice. Surg Endosc. 2001 15(9): 981-985
  23. Vithiananthan S, Cooper Z, Betten K, Stapleton G, Carter J, Huang E, Whelan R. Hybrid laparoscopic flexure takedown and open procedure for rectal resection is associated with significantly shorter length of stay than equivalent open resection. Dis Colon Rectum 2001 44(7): 927-935
  24. Huang EH, Whelan RL, Gleason NR, Maeda JS, Terry MB, Lee SW, Neugut AI, Forde KA. Increased incidence of colorectal adenomas in follow-up of patients with newly diagnosed hyperplastic polyps. Surgical Endoscopy 2001 15(7): 646-8
  25. Huang EH , Carter JJ, Whelan RL, Liu YH, Rosenberg JO, Rotterdam H, Schmidt AM, Stern DM, Forde KA. Colonoscopy in Mice. Surgical Endoscopy 2002 16(1): 22-24
  26. Kirman I, Cekic V, Poltaratskaia N, Asi Z, Bessler M, Huang EH, Forde KA, Whelan RL. Plasma from patients undergoing major open surgery stimulates in vitro tumor growth: Lower insulin-like growth factor binding protein 3 levels may, in part, account for this change. Surgery 2002 132(2): 186-92
  27. Huang EH, Forde KA. Surgical implications of colonoscopy. Semin Laparosc Surg 2003 10(1):13-18
  28. Kirman I, Cekec V, Poltaratskaia N, Asi Z, Conte S, Feingold D, Forde KA, Huang EH, Whelan RL. The percentage of CD31+ T cells decreases after open but not laparoscopic surgery. Surg Endosc 2003 17(5): 754-757
  29. Kirman I. Huang EH, Whelan RL. B cell response to tumor antigens is associated with depletion of progenitors in murine colocarcinoma. Surgery 2004;135(3):313-8
  30. Feingold DL, Addona T, Forde KA, Arnell TD, Carter JJ, Huang EH, Whelan RL. Safety and reliability of tattooing colorectal neoplasms prior to laparoscopic resection. J Gastrointest Surg. 2004; 8(5):543-6
  31. Dang LH, Chen F, Knock SA, Huang EH, Feng J, Appelman HD, Dang DT. CDX2 does not suppress tumorigenicity in the human gastric cancer cell line MKN45. Oncogene 2006; 25: 2048-2059
  32. Carter JJ, Feingold DL, Oh A, Kirman I, Wildbrett P, Stapleton G, Asi Z, Fowler R, Bhagat G, Huang EH, Fine RL, Whelan RL. Perioperative immunomodulation with Flt3 kinase ligand or a whole tumor cell vaccine is associated with a reduction in lung metastasis formation after laparotomy in mice. Surgical Innovation 2006; 13: 41-47
  33. Huang EH, Park JC, Appelman H, Weinberg AD, Banerjee M, Logsdon CD, Schmidt AM. Induction of inflammatory bowel disease accelerates adenoma formation in MIN+/- mice. Surgery 2006; 139: 782-788
  34. Dalerba P, Dylla SJ, Park, IK, Liu, R, Wang X, Cho RW, Hoey T, Gurney A, Huang EH, Simeone DM, Shelton AA, Parmiani G, Castelli C, Clarke MF. Phenotypic characterization of human colorectal “cancer stem cells”. PNAS 2007; 104: 10158-63
  35. Fuentes MK, Nigavekar SS, Arumugam T, Logsdon CD, Schmidt AM, Park JC, Huang EH. RAGE activation by S100P in colon cancer stimulates growth, migration and cell signaling pathways. Diseases of the Colon and Rectum 2007; 50(8): 1230-40
  36. Desai S, El Rayes B, Greenson J, Griffth K, Huang EH, Knol JA, Zalupski, MM. A phase II study of preoperative capecitabine and radiation therapy in patients with rectal cancer. American Journal of Clinical Oncology, 2007; 30(4): 340-5
  37. Boman BM, Huang E. Human colon cancer stem cells: a new paradigm in gastrointestinal oncology. J Clin Oncol. 2008 Jun 10;26(17):2828-38.

 
Biosketch
Education
9/1989-5/1984 Oberlin College, Ohio; B.A. Psychobiology, High Honors
9/1984-5/1989 Stanford University School of Medicine, Stanford California; M.D., Research Honors
 
Postdoctoral Training
6/1989-6/1990 Internship, General Surgery, The Ohio State University, Columbus, Ohio
7/1990-6/1992 Residency, General Surgery, The Ohio State University, Columbus, Ohio
7/1992-6/1995 Transplant Research, The Ohio State University, Columbus, Ohio
7/1995-6/1997 Residency, General Surgery, The Ohio State University, Columbus, Ohio
7/1997-6/1998 Colorectal Residency, Grant Medical center, Columbus, Ohio
 
Academic Appointments
7/1998-5/2003: Assistant Professor of Surgery, Columbia University, New York, New York
6/2003-12/2007: Assistant Professor of Surgery, University of Michigan, Ann Arbor, Michigan
1/2008-Present: Associate Professor of Surgery, University of Florida, Gainesville, Florida
11/2008-Present: Joint Associate Professor of Molecular Genetics and Microbiology, University of Florida, Gainesville, Florida

 

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