Philip A. Efron, MD

Assistant Professor of Surgery and Anesthesiology; Co-Director, Laboratory of Inflammation Biology and Surgical Science
Acute Care Surgery

phone: Office 352-273-5670; Lab 352-265-0494
fax: Office 352-273-5683; Lab 352-265-0676

Awards and Professional Interests - Research/Clinical Interests
Research Projects - References - Biosketch
Awards and Professional Interests
  • 1995: Sigma Xi, The Scientific Research Society (Swarthmore College Chapter)
  • 1999: Charles L. Wisseman, Jr. Award for Excellence in Microbiology and Immunology (University of Maryland School of Medicine)
  • 1995-1999: Honors at University of Maryland School of Medicine - Surgery Sub-Internship, Specialty Surgery, Junior Surgery, Neuroscience, Functional Systems, Microbiology, Pathology and Therapeutics
  • 2005: University of Florida Department of Surgery Research Day, Best Clinical Abstract
  • 2007: Edward R. Woodward Surgical Resident’s Award (University of Florida)
  • PROFESSIONAL CERTIFICATION AND MEMBERSHIPS
  • 2008: Diplomate, American Board of Surgery
  • 2007-Present: Member, Society of Critical Care Medicine
  • 2009-Present: Member, Shock Society
  • 2009-Present: Member, Surgical Infection Society
  • 2009-Present: Member, Association for Academic Surgery

Research/Clinical Interests
  • Dr. Efron has a professional interest in surgical critical care and trauma, both clinically as well as in the laboratory. He conducts basic science and translational research in sepsis and inflammation.
Research Projects
  • FUNDING
  • Funding Agency: National Institutes of Health; Co-Investigator; Grant title: 3R01GM040586-21S1,"Cytokine Regulation in Sepsis/Inflammation"; Period: 9/15/2009-08/31/2011

References
  1. PEER REVIEWED PUBLICATIONS
  2. 1. Schaffer MR, Tantry U, Efron PA, Ahrendt GM, Thornton FJ, Barbul A. Diabetes impaired healing and reduced wound nitric oxide synthesis: a possible pathophysiologic correlation. Surgery 121:513-9, 1997.
  3. 2. Schaffer MR, Efron PA, Thornton FJ, Klingel K, Gross SS, Barbul A. Nitric Oxide, an autocrine regulator of wound fibroblast synthetic function. Journal of Immunology 158:2375-81, 1997.
  4. 3. Efron P, Knudsen E, Hirshorn S, Copeland EM. Anaphylactic reaction to isosulfan blue used for sentinel node biopsy: case report and literature review. Breast Journal 8:396-9, 2002.
  5. 4. Efron PA, Beierle EA. Pediatric sand aspiration: case report and literature review. Pediatric Surgery International 19:409-12, 2003.
  6. 5. Efron PA, Moldawer LL. Blocking of IL-18: a tumor necrosis factor-alpha lesson already learned. Critical Care Medicine 32:2241-2, 2003.
  7. 6. Efron P, Moldawer L. Sepsis and the dendritic cell. Shock 20:386-401, 2003.
  8. 7. Efron PA, Moldawer LL. Cytokines and wound healing: the role of cytokine and anticytokine therapy in the repair response. Journal of Burn Care & Rehabilitation 25:149-60, 2004.
  9. 8. Efron PA, Tinsley K, Minnich DJ., Monterroso V, Wagner J, Lainee P, Lorre K, Swanson PE, Hotchkiss R, Moldawer LL. Increased lymphoid tissue apoptosis in bacteremic baboons. Shock 21:566:571, 2004.
  10. 9. Efron PA, Martins A, Minnich DJ, Tinsley K, Ungaro R, Bahjat FR, Hotchkiss R, Clare- Salzler M, Moldawer LL. Characterization of the systemic loss of dendritic cells in murine lymph nodes during polymicrobial sepsis. Journal of Immunology 173:3035-43, 2004.
  11. 10. Matsumoto T, Efron PA, Tsujimoto H, Tschoeke SK, Ungaro R, Fujita S, Foley DP, Hemming A, Moldawer LL. Splenic transposition is superior to caudal shunt as a model of murine total hepatic ischemia. Laboratory Investigation 85:90-8, 2005.
  12. 11. Womer KL, Peng R, Patton PR, Kaleem A, Bucci M, Murawski MR, Schold J, Efron PA, Hemming AW, Srinivas TR, Meier-Kriesche HU, Kaplan B, Clare-Salzler MJ. The effects of renal transplantation on circulating precursor dendritic cells. Transplantation Proceedings 37:3-6, 2005.
  13. 12. Lainee P, Efron PA, Tschoeke SK, Elies L, Lorre K, Moldawer LL. Delayed neutralization of interferon-gamma prevents lethality in primate Gram negative bacteremic shock. Critical Care Medicine 33:797-805, 2005.
  14. 13. Oberholzer A., Oberholzer C, Efron PA, Scumpia PO, Uchida T, Bahjat K, Ungaro R, Tannahill CL, Murday M, Bahjat FR, Tsai V, Hutchins B, Moldawer LL, LaFace D, Clare- Salzler MJ. Functional modification of dendritic cells with recombinant adenovirus encoding interleukin 10 for the treatment of sepsis. Shock 6:507-15, 2005.
  15. 14. Efron PA, Tsujimoto H, Bahjat FR, Ungaro R, Debernardis J, Tannahill C, Baker HV, Edwards CK, Moldawer LL. Differential maturation of murine bone-marrow derived dendritic cells with lipopolysaccharide and tumor necrosis factor-alpha. Journal of Endotoxin Research 11:145-60, 2005.
  16. 15. Tsujimoto H, Uchida T, Efron PA, Verma A, Scumpia PO, Matsumoto T, Tschoeke SV, Ungaro RF, Ono S, Seki S, Clare-Salzler M, Baker HV, Mochizuki H, Ramphal R, Moldawer LL. Flagellin enhances NK cell proliferation and activation both directly and through dendritic cell-NK cell interactions. Journal of Leukocyte Biology 78:888-97, 2005.
  17. 16. Scumpia PO, McAuliffe PF, O’Malley KA, Ungaro R, Uchida T, Matsumoto T, Remick DG, Clare-Salzler MJ, Moldawer LL, Efron PA. CD11c+ dendritic cells are required for survival in murine polymicrobial sepsis. Journal of Immunology 175:3282-6, 2005.
  18. 17. Womer KL, Peng R, Patton PR, Murawski MR, Bucci M, Kaleem A, Schold J, Efron PA, Hemming AW, Srinivas TR, Meier-Kriesche HU, Kaplan B, Clare-Salzler MJ. The effects of renal transplantation on peripheral blood dendritic cells. Clinical Transplantation 5:659-67, 2005.
  19. 18. Schreiber J, Efron PA, Park, J, Moldawer LL, Barbul A. Adenoviral gene transfer of an NF-kappaB super-repressor increases collagen deposition in rodent cutaneous wound healing. Surgery 138:940-6, 2005.
  20. 19. McAuliffe PF, Efron PA, Scumpia PO, Uchida T, Mutschlecner SC, Rout WR, Moldawer LL, Cendan JC. Varying Blood Monocyte and Dendritic Cell Responses After Laparoscopic Versus Open Gastric Bypass Surgery. Obesity Surgery 15:1424-31, 2005.
  21. 20. Efron PA, Chen MK, Iyengar M, Dai W, Nagaram A, Beierle EA. Differential response of neuroblastoma to TRAIL is independent of PIK3/Akt. Journal of Pediatric Surgery 41:1072-80, 2005.
  22. 21. Sethu P, Moldawer LL, Mindrinos MN, Scumpia PO, Tannahill CL, Wilhelmy J, Efron PA, Tompkins RG, Toner M and the Inflammation and Host Response to Injury Large Scale Collaborative Research Program. Microfluidic Isolation of Leukocytes from Whole Blood for Microarray Analysis. Analytical Chemistry 78:5433-61, 2005.
  23. 22. McAuliffe PM, Murday ME, Efron PA, Scumpia PO, Abouhamze A, Tannahill CL, Hutchins B, LaFace D, Moldawer LL. Dose-Dependent Improvements in Outcome with Adenoviral Expression of Interleukin-10 in a Murine Model of Acute Lung Injury and Multisystem Organ Failure. Gene Therapy 13:276-82, 2006.
  24. 23. Tsujimoto H, Ono S, Majima T, Efron PA, Matsumoto, Kinoshita M, Hiraide H, Moldawer LL, Mochizuki H. Differential Toll-like receptor expression after ex vivo lipopolysaccharide exposure in patients with sepsis and following surgical stress. Journal of Clinical Immunology 119:180-7, 2006.
  25. 24. Tsujimoto H, Efron PA, Matsumoto T, Ungaro RF, Abouhamze A, Ono S, Mochizuki H, Moldawer LL. Maturation of murine bone marrow-derived dendritic cells with poly(I:C) produces altered TLR-9 expression and response to CpG DNA. Immunology Letters 107:155-62, 2006.
  26. 25. Matsumoto T, O’Malley K, Efron PA, Burger C, Scumpia PO, McAuliffe PF, Uchida T, Tschoeke SK, Fujita S, Moldawer LL, Hemming A, Foley DP. Interleukin-6 and STAT3 protect the liver from hepatic ischemia and reperfusion injury during ischemic preconditioning. Surgery, 140:793-802, 2006.
  27. 26. Scumpia PO, Delano MJ, Kelly KM, Efron PA, McAuliffe PF, O’Malley KA, Brusko T, Ungaro R, Barker T , Atkinson MA, Reeves WH, Clare-Salzler MJ, Moldawer LL. Increased natural CD24+CD25+ regulatory T cells and their suppressor activity do not contribute to mortality in murine polymicrobial sepsis. Journal of Immunology 177:7943-9, 2006.
  28. 27. Tsujimoto H, Ono S, Efron PA, Scumpia PO, Moldawer LL, Mochizuki H. Role of Toll-like receptors in the development of sepsis. Shock 29:315-21, 2008.
  29. 28. Cudnik R, Efron PA, Chen MK, Reith JD, Beierle EA. Mesenteric lipoblastoma: a rare location in children. Journal of Pediatric Surgery 42:e5-7, 2008.
  30. 29. Efron PA, Chen MK, Glavin FL, Kays DW, Beierle EA. Pediatric basal cell carcinoma: case reports and literature review. Journal of Pediatric Surgery 43:2277-80, 2008.
  31. 30. Efron PA, Masuski J. Clostridium difficile colitis. Surgical Clinics of North America 89:483-500, 2009.
  32. 31. Efron PA, Matsumoto T, McAuliffe PF, Scumpia PO, Ungaro R, Fujita S, Moldawer LL, Foley D, Hemming AW. Major hepatectomy induces phenotypic changes in circulating dendritic cells and monocytes. Journal of Clinical Immunology, (2009) in press.

 
Biosketch
Education
1991-1995Swarthmore College, Swarthmore, PA, Bachelor of Arts, Biology
1995-1999University of Maryland School of Medicine, Baltimore, MD, Medical Doctorate
 
Postdoctoral Training
1997-2007General Surgical Residency, University of Florida, Gainesville, FL
2001-2004T-32 Research Fellow under Lyle Moldawer, Ph.D., Laboratory of Inflammation Biology and Surgical Science, University of Florida, Gainesville, FL
2007-2008Surgical Critical Care Fellowship, Barnes-Jewish Hospital, Washington University in Saint Louis, Saint Louis, MO
 
Academic Appointments
2008-PresentAssistant Professor of Surgery and Anesthesiology, Division of Acute Care Surgery and Surgical Critical Care, University of Florida, Gainesville, FL
2008-PresentCo-Director, Laboratory of Inflammation Biology and Surgical Science, Department of Surgery, University of Florida, Gainesville, FL

 

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